Neurotoxicity Pathways in Drosophila Models of the Polyglutamine Disorders.

Although polyglutamine expansion diseases are the most common genetically inherited neurodegenerative disorders, the key pathogenic mechanisms that lead to neuronal cell death are unclear. The expansion of a polyglutamine tract in specific proteins is the defining molecular insult, leading to cell-type and region-specific neuronal death. Intraneuronal… CONTINUE READING