Neurotoxic phospholipase A2 toxicity model: An insight from mammalian cells.

Abstract

The molecular mechanism of action of presynaptically neurotoxic secreted phospholipases A2 (sPLA2s) has not been fully elucidated. We have recently proposed a model to explain one of the hallmarks of their action - the reduction in endocytosis leading to synaptic vesicle depletion in nerve terminals. Our results speak strongly in favor of a mechanism in… (More)
DOI: 10.4161/cib.23600

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Cite this paper

@article{Vardjan2013NeurotoxicPA, title={Neurotoxic phospholipase A2 toxicity model: An insight from mammalian cells.}, author={Nina Vardjan and Mojca Mattiazzi and Edward G. Rowan and Igor Kri{\vz}aj and Uro{\vs} Petrovi{\vc} and Toni Petan}, journal={Communicative & integrative biology}, year={2013}, volume={6 3}, pages={e23600} }