Neurotoxic peptides from the venom of the giant Australian stinging tree

  title={Neurotoxic peptides from the venom of the giant Australian stinging tree},
  author={E. Gilding and Sina Jami and Jennifer R Deuis and Mathilde R Israel and P. Harvey and Aaron G. Poth and Fabian B. H. Rehm and J. Stow and S. D. Robinson and K. Yap and Darren L Brown and B. Hamilton and D. Andersson and D. Craik and I. Vetter and T. Durek},
  journal={Science Advances},
The pain-inducing components of Australian stinging tree venom are miniproteins that modulate voltage-gated sodium channels. Stinging trees from Australasia produce remarkably persistent and painful stings upon contact of their stiff epidermal hairs, called trichomes, with mammalian skin. Dendrocnide-induced acute pain typically lasts for several hours, and intermittent painful flares can persist for days and weeks. Pharmacological activity has been attributed to small-molecule… Expand
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