Neurotoxic peptides from the venom of the giant Australian stinging tree

@article{Gilding2020NeurotoxicPF,
  title={Neurotoxic peptides from the venom of the giant Australian stinging tree},
  author={Edward K. Gilding and Sina Jami and Jennifer R. Deuis and Mathilde R. Israel and Peta J. Harvey and Aaron G. Poth and Fabian B. H. Rehm and Jennifer L. Stow and Samuel D. Robinson and Kuok Yap and Darren L. Brown and Brett R. Hamilton and David A. Andersson and David J. Craik and Irina Vetter and Thomas Durek},
  journal={Science Advances},
  year={2020},
  volume={6}
}
The pain-inducing components of Australian stinging tree venom are miniproteins that modulate voltage-gated sodium channels. Stinging trees from Australasia produce remarkably persistent and painful stings upon contact of their stiff epidermal hairs, called trichomes, with mammalian skin. Dendrocnide-induced acute pain typically lasts for several hours, and intermittent painful flares can persist for days and weeks. Pharmacological activity has been attributed to small-molecule… 
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