Neurotoxic peptides from the venom of the giant Australian stinging tree

@article{Gilding2020NeurotoxicPF,
  title={Neurotoxic peptides from the venom of the giant Australian stinging tree},
  author={Edward K. Gilding and Sina Jami and Jennifer R. Deuis and Mathilde R Israel and Peta J. Harvey and Aaron G. Poth and Fabian B. H. Rehm and Jennifer L. Stow and Samuel D. Robinson and Kuok Yap and Darren L Brown and Brett R Hamilton and David A. Andersson and David J. Craik and Irina Vetter and Thomas Durek},
  journal={Science Advances},
  year={2020},
  volume={6}
}
The pain-inducing components of Australian stinging tree venom are miniproteins that modulate voltage-gated sodium channels. Stinging trees from Australasia produce remarkably persistent and painful stings upon contact of their stiff epidermal hairs, called trichomes, with mammalian skin. Dendrocnide-induced acute pain typically lasts for several hours, and intermittent painful flares can persist for days and weeks. Pharmacological activity has been attributed to small-molecule… Expand
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