Neurotoxic factors released by stimulated human monocytes and THP-1 cells.

  title={Neurotoxic factors released by stimulated human monocytes and THP-1 cells.},
  author={Moonhee Lee and Kyoungho Suk and Yunhee Kang and E. G. McGeer P. L. McGeer and Patrick L. Mcgeer},
  journal={Brain research},
Activated monocytes/macrophages are known to release toxic materials. Identification of these materials is important for developing more effective treatments for inflammatory disorders where self attack occurs. We stimulated human monocytes and THP-1 cells with LPS/IFNγ and measured the toxic effects of their conditioned media against differentiated human NT-2 cells. Their cytotoxicity, as measured by LDH release, was reduced by half when their conditioned media was passed through a 3kDa cutoff… CONTINUE READING
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