• Corpus ID: 17066838

Neurotoxic effects of thimerosal at vaccines doses on the encephalon and development in 7 days-old hamsters

@inproceedings{Laurente2008NeurotoxicEO,
  title={Neurotoxic effects of thimerosal at vaccines doses on the encephalon and development in 7 days-old hamsters},
  author={Jonny Laurente and Fany Remuzgo and Betthina {\'A}valos and Johnnie Chiquinta and B Ponce and R Avenda{\~n}o and Luis E. Maya},
  year={2008}
}
Objectives: To determine if thimerosal administration in amounts equivalent to vaccines content produces neurotoxic effects on the encephalon in postnatal hamsters and on experimentation animal’s development. Design: Experimental, prospective, bioetapic study. Setting: San Fernando Faculty of Medicine, Universidad Nacional Mayor de San Marcos. Biological material: Seven daysold hamsters. Material: We divided 45 postnatal hamsters in three groups: group A (n=15), group B (n=15) and group C (n=15… 
Lasting neuropathological changes in rat brain after intermittent neonatal administration of thimerosal.
TLDR
Findings document neurotoxic effects of thimerosal, at doses equivalent to those used in infant vaccines or higher, in developing rat brain, suggesting likely involvement of this mercurial in neurodevelopmental disorders.
Transcriptomic analyses of neurotoxic effects in mouse brain after intermittent neonatal administration of thimerosal.
TLDR
Results indicate that higher dose of neonatal thimerosal-mercury is capable of inducing long-lasting substantial dysregulation of neurodevelopment, synaptic function, and endocrine system, which could be the causal involvements of autistic-like behavior in mice.
Effects of Thimerosal on Cerebellum Tissue and Neurodevelopmental Disorders Related Behaviors in Rats
TLDR
It is documented that probably the early postnatal THIM administration causes lasting neurobehavioral and histological impairments and these conditions could contribute to neurodevelopmental disorders.
Effects of Thimerosal on Cerebellum Tissue and Neurodevelopmental Disorders Related Behaviors in Rats
TLDR
It is documented that probably the early postnatal THIM administration causes lasting neurobehavioral and histological impairments and these conditions could contribute to neurodevelopmental disorders.
Effect of thimerosal on the neurodevelopment of premature rats
TLDR
The negative adverse consequences on neurodevelopment observed in the present study are consistent with previous studies and raised serious concerns about adverse neurodevelopmental disorder such as autism in humans following the ongoing worldwide routine administration of thimerosalcontaining vaccines to infants.
Induction of metallothionein in mouse cerebellum and cerebrum with low-dose thimerosal injection
TLDR
MT-1 and MT-3 mRNAs but not MT-2 mRNA are easily expressed in the cerebellum rather than in the Cerebrum by the injection of low-dose thimerosal, which helps to support the possible biological plausibility for how low- dose exposure to mercury fromThimerosal-containing vaccines may be associated with autism.
Examination of the Safety of Pediatric Vaccine Schedules in a Non-Human Primate Model: Assessments of Neurodevelopment, Learning, and Social Behavior
TLDR
This comprehensive 5-year case–control study, which closely examined the effects of pediatric vaccines on early primate development, provided no consistent evidence of neurodevelopmental deficits or aberrant behavior in vaccinated animals.
Thimerosal-Containing Hepatitis B Vaccination and the Risk for Diagnosed Specific Delays in Development in the United States: A Case-Control Study in the Vaccine Safety Datalink
TLDR
Though routine childhood vaccination may be an important public health tool to reduce the morbidity and mortality associated with infectious diseases, the present study supports an association between increasing organic-mercury exposure from Thimerosal-containing childhood vaccines and the subsequent risk of specific delays in development among males and females.
...
...

References

SHOWING 1-10 OF 141 REFERENCES
Neurotoxic effects of postnatal thimerosal are mouse strain dependent
TLDR
It is hypothesized that autoimmune propensity influences outcomes in mice following thimerosal challenges that mimic routine childhood immunizations, and these findings implicate genetic influences and provide a model for investigatingThimerosal-related neurotoxicity.
Comparison of Blood and Brain Mercury Levels in Infant Monkeys Exposed to Methylmercury or Vaccines Containing Thimerosal
TLDR
The results indicate that MeHg is not a suitable reference for risk assessment from exposure to thimerosal-derived Hg, and knowledge of the toxicokinetics and developmental toxicity ofThimerosal is needed to afford a meaningful assessment of the developmental effects of thimerosa-containing vaccines.
Neurodevelopmental Disorders after Thimerosal-Containing Vaccines: A Brief Communication
TLDR
An association between neurodevelopmental disorders and thimerosal-containing DTaP vaccines was found, but additional studies should be conducted to confirm and extend this study.
Neurotoxic character of thimerosal and the allometric extrapolation of adult clearance half‐time to infants
  • L. Magos
  • Environmental Science
    Journal of applied toxicology : JAT
  • 2003
TLDR
The decomposition rate of organomercurials and the potency of the blood–brain barrier increase with the size of the organic radical, and methylmercury damages the brain more than thimerosal does, so the safety margin is increased even if the clearances were the same.
Thimerosal Exposure in Infants and Developmental Disorders: A Retrospective Cohort Study in the United Kingdom Does Not Support a Causal Association
TLDR
With the possible exception of tics, there was no evidence that thimerosal exposure via DTP/DT vaccines causes neurodevelopmental disorders.
Comparison of organic and inorganic mercury distribution in suckling rat
TLDR
The results showed that the level of mercury was higher in the liver and kidney of the inorganic mercury group than in the thiomersal exposed group, however, the brain and blood concentrations of mercury were higher in The results need to be clarified by additional data on the kinetic pathways of ethylmercury compared with in organic mercury.
...
...