Neurotoxic effects of the anti-varicella zoster virus agent 2'-valeryl-6-methoxypurine arabinoside in monkeys and rats dosed orally for 90 days.

@article{Szczech1992NeurotoxicEO,
  title={Neurotoxic effects of the anti-varicella zoster virus agent 2'-valeryl-6-methoxypurine arabinoside in monkeys and rats dosed orally for 90 days.},
  author={G. Szczech and W. Tucker},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1992},
  volume={18 2},
  pages={
          314-20
        }
}
  • G. Szczech, W. Tucker
  • Published 1992
  • Medicine
  • Fundamental and applied toxicology : official journal of the Society of Toxicology
  • The 2'-valerate ester of 6-methoxypurine arabinoside (170U88), a nucleoside analog with anti-varicella zoster virus (VZV) activity, was given to monkeys and rats. In subchronic preclinical toxicity studies, dosing was by gavage to monkeys (distilled water vehicle) and rats (0.5% methylcellulose vehicle) for 90 days. Groups of 5 male and 5 female monkeys (Macaca fascicularis) were given 170U88 at 0, 25, 50, or 100 mg/kg/day. The daily dose was given in two equal portions with 6 hr between doses… CONTINUE READING
    3 Citations
    Preclinical development of antiviral drugs.
    • G. Szczech
    • Medicine
    • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
    • 1996
    • 15
    • PDF