• DOI:10.1093/toxsci/18.2.314
Corpus ID: 23784816

Neurotoxic effects of the anti-varicella zoster virus agent 2'-valeryl-6-methoxypurine arabinoside in monkeys and rats dosed orally for 90 days.

@article{Szczech1992NeurotoxicEO,
  title={Neurotoxic effects of the anti-varicella zoster virus agent 2'-valeryl-6-methoxypurine arabinoside in monkeys and rats dosed orally for 90 days.},
  author={G. Szczech and W. Tucker},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1992},
  volume={18 2},
  pages={
          314-20
        }
}

G. Szczech, W. Tucker

Published 1992

Medicine

Fundamental and applied toxicology : official journal of the Society of Toxicology

The 2'-valerate ester of 6-methoxypurine arabinoside (170U88), a nucleoside analog with anti-varicella zoster virus (VZV) activity, was given to monkeys and rats. In subchronic preclinical toxicity studies, dosing was by gavage to monkeys (distilled water vehicle) and rats (0.5% methylcellulose vehicle) for 90 days. Groups of 5 male and 5 female monkeys (Macaca fascicularis) were given 170U88 at 0, 25, 50, or 100 mg/kg/day. The daily dose was given in two equal portions with 6 hr between doses… CONTINUE READING

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