Neurotoxic effects of interleukin-6 and sodium nitroprusside on cultured rat hippocampal neurons.

@article{Ma2000NeurotoxicEO,
  title={Neurotoxic effects of interleukin-6 and sodium nitroprusside on cultured rat hippocampal neurons.},
  author={Tso Ching Ma and Xing Zu Zhu},
  journal={Arzneimittel-Forschung},
  year={2000},
  volume={50 6},
  pages={512-4}
}
The neurotoxicity of interleukin-6 (IL-6) and sodium nitroprusside (SNP, CAS 13755-38-9) was examined using primary cultures of rat hippocampal neurons. The cell viability was significantly reduced after the cultures were co-incubated with IL-6 4, 40, 400 ng/ml or SNP 1, 10, 100 mumol/l for 24 h. In addition, N omega-nitro-L-arginine (NNA, CAS 2149-70-4) at 0.1 mmol/l, when co-added with IL-6 400 ng/ml in cultures, significantly increased IL-6 reduced viability from 78.3 +/- 6.7% to 113.3… CONTINUE READING