Neurotoxic damage of granule cells in the dentate gyrus and the cerebellum and cognitive deficit following neonatal administration of phenytoin in mice.

@article{Ogura2002NeurotoxicDO,
  title={Neurotoxic damage of granule cells in the dentate gyrus and the cerebellum and cognitive deficit following neonatal administration of phenytoin in mice.},
  author={Hiroo Ogura and Mineo Yasuda and Shigenobu Nakamura and Hiroshi Yamashita and Katsuhiko Mikoshiba and Hiromitsu Ohmori},
  journal={Journal of neuropathology and experimental neurology},
  year={2002},
  volume={61 11},
  pages={
          956-67
        }
}
The use of antiepileptic drugs during human gestation probably increases the risk of causing CNS disorders in later life. In brain, granule cells in the dentate gyrus (DG) and cerebellum are still developing in the last trimester of human gestation and a similar development is taking place during the mouse perinatal period. We treated newborn C57BL/6 mice orally with 35 mg/kg phenytoin (PHT) daily during postnatal days (PD) 5 to 14. Histopathological investigation revealed that the layer of… CONTINUE READING
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