Neurotoxic cations induce membrane rigidification and membrane fusion at micromolar concentrations.

@article{Deleers1986NeurotoxicCI,
  title={Neurotoxic cations induce membrane rigidification and membrane fusion at micromolar concentrations.},
  author={Marie Deleers and J P Servais and Ernst W{\"u}lfert},
  journal={Biochimica et biophysica acta},
  year={1986},
  volume={855 2},
  pages={271-6}
}
The effect of the neurotoxic cations aluminum, cadmium and manganese on membranes was examined in sonicated unilamellar vesicles containing phosphatidylserine and compared to the effect of Ca2+. Fusion of membranes was monitored by assessing the resonance energy transfer between N-(7-nitrobenz-2-oxa-1,3-diazol-4-y)phosphatidylethanolamine and N-(lissamine-rhodamine B-sulfonyl)phosphatidylethanolamine. Self-quenching of high concentrations of carboxyfluorescein in liposomes was used to… CONTINUE READING