Neurotoxic catecholamine metabolite in nociceptors contributes to painful peripheral neuropathy.

@article{Dina2008NeurotoxicCM,
  title={Neurotoxic catecholamine metabolite in nociceptors contributes to painful peripheral neuropathy.},
  author={Olayinka A Dina and Sachia G. Khasar and Nicole Alessandri-Haber and Oliver Bogen and Xiaojie Chen and Paul Green and David B. Reichling and Robert O Messing and Jon D Levine},
  journal={The European journal of neuroscience},
  year={2008},
  volume={28 6},
  pages={1180-90}
}
The neurotoxic effects of catecholamine metabolites have been implicated in neurodegenerative diseases. As some sensory neurons express tyrosine hydroxylase and monoamine oxidase (MAO), we investigated the potential contribution of catecholamine metabolites to neuropathic pain in a model of alcoholic neuropathy. The presence of catecholamines in sensory neurons is supported by capsaicin-stimulated epinephrine release, an effect enhanced in ethanol-fed rats. mRNA for enzymes in dorsal root… CONTINUE READING
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