Neurotoxic and neurobehavioral effects of kynurenines in adult insects.

  title={Neurotoxic and neurobehavioral effects of kynurenines in adult insects.},
  author={Anja Cerstiaens and Jurgen Huybrechts and Stephen Kotanen and Ilya Lebeau and Karen Meylaers and Arnold De Loof and Liliane Schoofs},
  journal={Biochemical and biophysical research communications},
  volume={312 4},
Kynurenines are endogenous metabolites of tryptophan, which are studied extensively in vertebrates with respect to their etiological role in the pathology of various neurodegenerative disorders. In insects, metabolites of the kynurenic pathway are present in peak concentrations in the hemolymph of holometabolic species during pupation and just before eclosion. Unlike in larvae, these compounds cause severe motor dysfunction in adult species. Adult flesh flies were injected with various… CONTINUE READING


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