Neurotoxic action of veratridine in rat brain neuronal cultures: mechanism of neuroprotection by Ca++ antagonists nonselective for slow Ca++ channels.

Abstract

The effect of various Ca++ antagonists and local anesthetics on neuronal cell degeneration induced by veratridine was studied in primary rat brain neuronal cultures. Cell death was quantified by measuring lactate dehydrogenase (LDH) released in the culture medium. The neuronal cell degeneration was Ca+(+)-dependent because, in the absence of extracellular… (More)

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@article{Pauwels1990NeurotoxicAO, title={Neurotoxic action of veratridine in rat brain neuronal cultures: mechanism of neuroprotection by Ca++ antagonists nonselective for slow Ca++ channels.}, author={Petrus Johan Pauwels and Harrie P Van Assouw and Liesbet M Peeters and Julie Leysen}, journal={The Journal of pharmacology and experimental therapeutics}, year={1990}, volume={255 3}, pages={1117-22} }