Neurotoxic Effects Induced by Intracerebral and Systemic Injection of Paraquat in Rats

  title={Neurotoxic Effects Induced by Intracerebral and Systemic Injection of Paraquat in Rats},
  author={Maria Tiziana Corasaniti and Giacinto Bagetta and Paola Rodin{\`o} and Santo Gratteri and Giuseppe Nistic{\'o}},
  journal={Human \& Experimental Toxicology},
  pages={535 - 539}
1 The neurotoxic effects elicited by paraquat after systemic and intracerebral injection were studied in rats. 2 Intrahippocampal microinfusion of paraquat (0.1 μmol) produced behavioural stimulation and electrocortical (ECoG) excitation followed, at 24 h, by multifocal brain damage. Similarly, microinfusion of paraquat (0.2-0.4 μmol) into the locus coeruleus, substantia nigra or into the raphe nuclei, where noradrenergic, dopaminergic and serotonergic neurons are present, respectively… 

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