Neurotoxic APP C-terminal and β-amyloid domains colocalize in the nuclei of substantia nigra pars reticulata neurons undergoing delayed degeneration

@article{Degiorgio2000NeurotoxicAC,
  title={Neurotoxic APP C-terminal and β-amyloid domains colocalize in the nuclei of substantia nigra pars reticulata neurons undergoing delayed degeneration},
  author={Lorraine A Degiorgio and Lorraine A DeGiorgio and Teresa A Milner and Bruno Conti and Bruce T. Volpe},
  journal={Brain Research},
  year={2000},
  volume={874},
  pages={137-146}
}
Increased amyloid precursor protein (APP) expression and intracellular accumulation of its toxic fragments have been associated with acute neuronal death processes. However, the role of APP fragments in delayed neurodegeneration remains poorly understood. We have characterized the appearance of APP domains in rat substantia nigra pars reticulata (SNpR) neurons targeted for delayed degeneration following neurotoxic striatal lesion. From 4 to 8 days postlesion (dpl) SNpR neurons ipsilateral to… CONTINUE READING