Neurotherapeutics: Emerging Strategies

  title={Neurotherapeutics: Emerging Strategies},
  author={Linda M. Pullan and Jitendra B. Patel},
The neurobiology of antiepileptic drugs
The subtle biophysical modifications in channel behaviour that are induced by AEDs are often functionally opposite to defects in channel properties that are caused by mutations associated with epilepsy in humans.
The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease.
Channel-level factors may allow memantine to block channel activity induced by low, tonic levels of glutamate--an action that might contribute to symptomatic improvement and could theoretically protect against weak excitotoxicity--while sparing synaptic responses required for normal behavioral functioning, cognition and memory.
Revisiting AMPA Receptors as an Antiepileptic Drug Target
Promising clinical studies with AMPA receptor antagonists, including the potent noncompetitive antagonist perampanel, are once again focusing attention on AMPA receptors as a drug target for epilepsy therapy.
Peptide receptors as targets for anxiolytic drugs
The research so far has been conducted in animals, but human data have started to accumulate, and the development of specific receptor ligands (agonists and antagonists) helps to elucidate their functional role.
The neuropharmacology of the ketogenic diet.
The Pharmacologic Basis of Antiepileptic Drug Action
This review summarizes the current understanding of the molecular targets of clinically significant AEDs, comparing and contrasting their differing mechanisms of action.
Glutamate receptors in epilepsy.
  • A. Chapman
  • Biology, Psychology
    Progress in brain research
  • 1998
Neocortical Potassium Currents Are Enhanced by the Antiepileptic Drug Lamotrigine
Summary:  Purpose: We used field‐potential recordings in slices of rat cerebral cortex along with whole‐cell patch recordings from rat neocortical cells in culture to test the hypothesis that the