Neurotensin signaling regulates stem-like traits of glioblastoma stem cells through activation of IL-8/CXCR1/STAT3 pathway.

@article{Zhou2014NeurotensinSR,
  title={Neurotensin signaling regulates stem-like traits of glioblastoma stem cells through activation of IL-8/CXCR1/STAT3 pathway.},
  author={Ji Yin Zhou and Liang Yi and Qing Ouyang and Lunshan Xu and Hongjuan Cui and Minhui Xu},
  journal={Cellular signalling},
  year={2014},
  volume={26 12},
  pages={2896-902}
}
We recently found that neurotensin (NTS) and its primary receptor NTSR1 play a crucial role in glioblastoma cell proliferation and invasion. However, very little is known regarding the functional role of NTS/NTSR1 signaling in glioblastoma stem cells (GSCs). Here, we showed that NTSR1 is highly expressed in GSCs than its non-GSC counterparts. Pharmacological blockade with SR48692 or lentivirus mediated knockdown of NTSR1 efficiently reduced the sphere-forming ability and expression of stem cell… CONTINUE READING
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