Neurotensin receptors: Binding properties, transduction pathways, and structure

@article{Vincent2005NeurotensinRB,
  title={Neurotensin receptors: Binding properties, transduction pathways, and structure},
  author={Jean Pierre Vincent},
  journal={Cellular and Molecular Neurobiology},
  year={2005},
  volume={15},
  pages={501-512}
}
  • J. Vincent
  • Published 1 October 1995
  • Biology
  • Cellular and Molecular Neurobiology
SummaryNeurotensin is a 13-amino acid peptide (pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu) originally isolated from hypothalami (Carraway and Leeman, 1973) and later from intestines (Kitabgiet al., 1976) of bovine. The peptide is present throughout the animal kingdom, suggesting its participation to important processes basic to animal life (Carrawayet al., 1982). Neurotensin and its analogue neuromedin-N (Lys-Ile-Pro-Tyr-Ile-Leu) (Minaminoet al., 1984) are synthesized by a common… 

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References

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The Neurotensin Receptor from Mammalian Brain

TLDR
The structural and functional properties of neurotensin binding sites have been characterized in a number of tissue preparations and cell cultures of neural or nonneural origin and some of these sites represent functional neurotensIn receptors since they are coupled to GTP-binding proteins and regulate intracellular levels of second messengers such as cAMP, cGMP, and inositol phosphates.

High‐Affinity Receptor Sites and Rapid Proteolytic Inactivation of Neurotensin in Primary Cultured Neurons

TLDR
The binding parameters as well as the specificity of these receptors toward neurotensin analogues reveal close similarities between the binding sites present in primary cultured neurons and those described in other membrane preprations or cells.

In vivo and in vitro structure-activity studies with peptide and pseudopeptide neurotensin analogs suggest the existence of distinct central neurotensin receptor subtypes.

TLDR
The results show that NT receptors in homogenates from newborn mouse and rat brain and from COS 7 cells transfected with the cloned high-affinity NT receptor from the adult rat brain displayed virtually identical structure-activity relationships toward a series of 12 peptide and pseudopeptide NT analogs.

THE MANIFOLD ACTIONS OF NEUROTENSIN: A FIRST SYNTHESIS *

TLDR
NT is a substance that derives from neuroectodermal cells of the primitive neural crest, which is destined to form the nervous system and part of the gastrointestinal tract, and in this respect NT is typical of its class.

Monoiodo-[ Trp " ] neurotensin , a Highly Radioactive Ligand of Neurotensin Receptors

TLDR
The binding isotherm was biphasic and could be described by postulating the existence of two different classes of independent binding sites with dissociation constants of 0.1 and 4.7 m; the specificity of a series of neurotensin analogues for both high and low affinity binding sites was the same as that previously observed in other neurotensIn radioreceptor assays.

Phospholipase C activation by neurotensin and neuromedin N in Chinese hamster ovary cells expressing the rat neurotensin receptor.

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