Neurotensin inhibits neuronal Na+,K+-ATPase activity through high affinity peptide receptor.

@article{Ordieres2000NeurotensinIN,
  title={Neurotensin inhibits neuronal Na+,K+-ATPase activity through high affinity peptide receptor.},
  author={Mar{\'i}a Graciela L{\'o}pez Ordieres and Georgina Rodr{\'i}guez de Lores Arnaiz},
  journal={Peptides},
  year={2000},
  volume={21 4},
  pages={571-6}
}
Neurotensin is a peptide present in mammalian CNS and peripheral tissues, which may play a major role in neurotransmission or neuromodulation, subserving diverse physiological functions. We studied the effect of added neurotensin on ATPase activities in synaptosomal membranes isolated from rat cerebral cortex. Neurotensin at 3 x 10(-8)-3 x 10(-6) M concentration decreased 20-44% Na+,K+-ATPase activity but failed to modify Mg2+-ATPase activity; lower neurotensin concentrations (3 x 10(-14)-3 x… CONTINUE READING

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