Neurotensin-induced myocardial noradrenergic effects in spontaneously hypertensive rats.

@article{Osadchii2006NeurotensininducedMN,
  title={Neurotensin-induced myocardial noradrenergic effects in spontaneously hypertensive rats.},
  author={Oleg E Osadchii and Angela Jill Woodiwiss and Dawn A J Deftereos and Gavin Robert Norton},
  journal={Journal of cardiovascular pharmacology},
  year={2006},
  volume={47 2},
  pages={221-7}
}
Although increases in myocardial synaptic norepinephrine concentrations contribute toward the progression to heart failure in hypertension, the stimuli for norepinephrine release are unclear. In this study we explored whether neurotensin, a neuropeptide found in heart tissue, could modify myocardial norepinephrine release in spontaneously hypertensive rats (SHR). Prior to the development of cardiac decompensation, baseline coronary effluent norepinephrine concentrations were higher in isolated… CONTINUE READING