Neurotensin enhances agonist-induced cAMP accumulation in PC3 cells via Ca2+-dependent adenylyl cyclase(s)

@article{Carraway1998NeurotensinEA,
  title={Neurotensin enhances agonist-induced cAMP accumulation in PC3 cells via Ca2+-dependent adenylyl cyclase(s)},
  author={R. Carraway and S. P. Mitra},
  journal={Molecular and Cellular Endocrinology},
  year={1998},
  volume={144},
  pages={47-57}
}
  • R. Carraway, S. P. Mitra
  • Published 1998
  • Chemistry, Medicine
  • Molecular and Cellular Endocrinology
  • A human prostate cancer cell line (PC3) with abundant neurotensin (NT) receptors was used to demonstrate that NT potentiated 3',5'-cyclic adenosine monophate (cAMP) accumulation in response to a variety of stimuli, including both direct forskolin (F) and indirect (prostaglandin, (PGE2), isoproterenol (ISO) and cholera toxin (CTx)) activators of adenylyl cyclase. Several mechanisms were investigated and our results indicated an effect on the rate of cAMP formation and not on degradation or… CONTINUE READING
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