Neurotensin enhances agonist-induced cAMP accumulation in PC3 cells via Ca2+-dependent adenylyl cyclase(s)

@article{Carraway1998NeurotensinEA,
  title={Neurotensin enhances agonist-induced cAMP accumulation in PC3 cells via Ca2+-dependent adenylyl cyclase(s)},
  author={R. Carraway and S. P. Mitra},
  journal={Molecular and Cellular Endocrinology},
  year={1998},
  volume={144},
  pages={47-57}
}
  • R. Carraway, S. P. Mitra
  • Published 1998
  • Chemistry, Medicine
  • Molecular and Cellular Endocrinology
    • A human prostate cancer cell line (PC3) with abundant neurotensin (NT) receptors was used to demonstrate that NT potentiated 3',5'-cyclic adenosine monophate (cAMP) accumulation in response to a variety of stimuli, including both direct forskolin (F) and indirect (prostaglandin, (PGE2), isoproterenol (ISO) and cholera toxin (CTx)) activators of adenylyl cyclase. Several mechanisms were investigated and our results indicated an effect on the rate of cAMP formation and not on degradation or… CONTINUE READING
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    Background Citations
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    Results Citations
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    Citation Type

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    Ca2+ channel blockers enhance neurotensin (NT) binding and inhibit NT-induced inositol phosphate formation in prostate cancer PC3 cells.
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    Growth inhibition and apoptosis induced by P2Y2 receptors in human colorectal carcinoma cells: involvement of intracellular calcium and cyclic adenosine monophosphate
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    Metalloproteinase-dependent Transforming Growth Factor-α Release Mediates Neurotensin-stimulated MAP Kinase Activation in Human Colonic Epithelial Cells*
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    Prostate Cancer Cell Growth: Role of Neurotensin in Mediating Effect of Dietary Fat and Mechanism of Action
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    Neurotensin as a source of cyclic AMP and co-mitogen in fibrolamellar hepatocellular carcinoma
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    The signaling signature of the neurotensin type 1 receptor with endogenous ligands
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    The mechanisms underlying the anti-cancer activity of substance-P analogues
    CHAPTER 102 – Neurotensin

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