Neurotensin-deficient mice show altered responses to antipsychotic drugs.

@article{Dobner2001NeurotensindeficientMS,
  title={Neurotensin-deficient mice show altered responses to antipsychotic drugs.},
  author={P. R. Dobner and Jim Fadel and Nancy Deitemeyer and Robert E. Carraway and Ariel Y. Deutch},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 14},
  pages={8048-53}
}
The peptide transmitter neurotensin (NT) exerts diverse neurochemical effects that resemble those seen after acute administration of antipsychotic drugs (APDs). These drugs also induce NT expression in the striatum; this and other convergent findings have led to the suggestion that NT may mediate some APD effects. Here, we demonstrate that the ability of the typical APD haloperidol to induce Fos expression in the dorsolateral striatum is markedly attenuated in NT-null mutant mice. The induction… CONTINUE READING
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Handbook of Experimental Pharmacology: Antipsychotics, ed

  • A. Y. Deutch
  • 1996

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