Neurotensin Gene Expression and Behavioral Responses Following Administration of Psychostimulants and Antipsychotic Drugs in Dopamine D3 Receptor Deficient Mice

@article{Betancur2001NeurotensinGE,
  title={Neurotensin Gene Expression and Behavioral Responses Following Administration of Psychostimulants and Antipsychotic Drugs in Dopamine D3 Receptor Deficient Mice},
  author={Catalina Betancur and Isabelle L{\'e}p{\'e}e-Lorgeoux and Mich{\`e}le Cazillis and Domenico Accili and Sara Fuchs and William Rost{\`e}ne},
  journal={Neuropsychopharmacology},
  year={2001},
  volume={24},
  pages={170-182}
}
Exposure to psychostimulants and antipsychotics increases neurotensin (NT) gene expression in the striatum and nucleus accumbens. To investigate the contribution of D3 receptors to these effects we used mice with targeted disruption of the D3 receptor gene. Basal NT mRNA expression was similar in D3 receptor mutant mice and wild-type animals. Acute administration of haloperidol increased NT gene expression in the striatum in D3+/+, D3+/− and D3−/− mice. Similarly, acute cocaine and amphetamine… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 64 references

Dopamine D3 receptor mutant mice exhibit increased behavioral sensitivity to concurrent stimulation of D1 and D2 receptors

  • M Xu, TE Koeltzow, +7 authors S Tonegawa
  • Neuron
  • 1997
Highly Influential
5 Excerpts

Similar Papers

Loading similar papers…