Neurotensin-Deficient Mice Have Deficits in Prepulse Inhibition: Restoration by Clozapine but Not Haloperidol, Olanzapine, or Quetiapine

  title={Neurotensin-Deficient Mice Have Deficits in Prepulse Inhibition: Restoration by Clozapine but Not Haloperidol, Olanzapine, or Quetiapine},
  author={Becky Kinkead and Paul R. Dobner and Vasili Egnatashvili and T. Scott Murray and N Deitemeyer and Charles B. Nemeroff},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={256 - 264}
  • B. Kinkead, P. Dobner, C. Nemeroff
  • Published 1 October 2005
  • Psychology, Biology, Medicine
  • Journal of Pharmacology and Experimental Therapeutics
Prepulse inhibition (PPI) of the acoustic startle reflex is a commonly used measure of preattentive sensorimotor gating. Disrupted PPI in rodents represents an animal model of the sensorimotor gating deficits characteristic of schizophrenia. The neurotensin (NT) system is implicated in the pathophysiology of schizophrenia, and NT has been hypothesized to act as an endogenous antipsychotic. In rats, NT receptor agonists restore PPI disrupted by dopamine receptor agonists and N-methyl-d-aspartate… 

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