Neurotensin: dual roles in psychostimulant and antipsychotic drug responses.

  title={Neurotensin: dual roles in psychostimulant and antipsychotic drug responses.},
  author={P. R. Dobner and Ariel Y. Deutch and Jim Fadel},
  journal={Life sciences},
  volume={73 6},
Central administration of neurotensin (NT) results in a variety of neurobehavioral effects which, depending upon the administration site, resemble the effects of antipsychotic drugs (APDs) and psychostimulants. All clinically effective APDs exhibit significant affinities for dopamine D(2) receptors, supporting the hypothesis that an increase in dopaminergic tone contributes to schizophrenic symptoms. Psychostimulants increase extracellular dopamine (DA) levels and chronics administration can… CONTINUE READING


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