Neurosyphilis: An Uncommon Cause of Dementia

  title={Neurosyphilis: An Uncommon Cause of Dementia},
  author={Avinash Rao and Ariba Khan and Kanwardeep Singh and D. L. Anderson and Michael L. Malone},
  journal={Journal of the American Geriatrics Society},
adults because of accompanying diseases. Systemic lupus erythematosus is rare, especially in older people. A search of the literature for LO-SLE uncovered three SLE cases in individuals aged 90 and older, each of whom had different clinical presentations and organ involvement, although they had in common that they met fewer diagnostic criteria than younger individuals and were treated less aggressively. The current case differs from these three because of renal involvement and hemolytic anemia… 
7 Citations

Neurosyphilis Mimicking Behavioral Variant of Frontotemporal Dementia in a 59-Year-Old Man

  • P. CaroppoC. Villa S. Prioni
  • Psychology, Medicine
    Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology
  • 2022
It is demonstrated that in some instances, neurosyphilis can mimic frontotemporal dementia and be considered in the differential diagnosis of bvFTD, particularly when psychiatric symptoms and a rapid cognitive decline are noted, even in the presence of brain atrophy and/or hypometabolism.

The effect of a large dose of intravenous immunoglobulin on general paresis of the insane

It is hypothesize that patients with GPI treated with IVIG and penicillin G would have better outcomes than those treated with peniillin G alone, and may be introduced as a necessary treatment for GPI.

Trends in the incidence of syphilis in the middle‐aged and older adults in Japan: A nationwide observational study, 2009–2019

This study aimed to investigate the national trend of syphilis cases in Japan and found that the number of cases is increasing among middle‐aged and older adults and women.

Neurocognitive Disorders in Old Age: Alzheimer’s Disease, Frontotemporal Dementia, Dementia with Lewy Bodies, and Prion and Infectious Diseases

Dementia is a clinical syndrome of cognitive decline resulting in impaired activities of daily living. It affects a person in their personhood, which, together with behavioural and psychological

Medial temporal lobe atrophy as a predictor of poor cognitive outcomes in general paresis

The effect of penicillin therapy on clinical outcomes vary among patients with general paresis and biomarkers that might serve as predictors of clinical outcomes in GP are explored.

Primary Care Mental Health in Older People: A Global Perspective

Efforts to improve mental wellbeing of older adults should include tackling loneliness, and Collaborative care, bringing together health and social services, is a good way of managing mental health problems in older adults.


Introdução: A sífilis é uma infecção sexualmente transmissível de grande relevância atual que pode evoluir com neuroinfecção, se não tratada precocemente. A apresentação clínica pode se manifestar



Late-Onset Systemic Lupus Erythematosus: A Personal Series of 47 Patients and Pooled Analysis of 714 Cases in the Literature

The clinical pattern of late-onset SLE is characterized by a lower disease severity, and the reduced survival observed in this group seems to result mainly from the consequences of aging.

Late-onset systemic lupus erythematosus: clinical features, course, and prognosis

Despite the less major organ involvement and more benign course of disease, late-onset SLE has poorer prognosis, because of the higher frequency of comorbid conditions and higher organ damage, due to the aging and longer exposition to a classical vascular risk factors.

A case of very-late-onset systemic lupus erythematosus

Administration of prednisolone 20 mg/day resulted in a marked improvement in fever, pleuritis, and laboratory findings in a case of very-late-onset SLE that occurred at the age of 93.

REVIEW: Neurosyphilis: A Historical Perspective and Review

  • K. Ghanem
  • Medicine, Psychology
    CNS neuroscience & therapeutics
  • 2010
The clinical manifestations, diagnosis, and therapy of neurosyphilis are summarized, focusing on areas of continued controversy, and highlighting several important questions that remain unanswered.

A case of very late-onset systemic lupus erythematosus and updated pooled analysis of late-onset cases in the literature

It was found that the organ damages and severity of lupus disease of old-onset SLE were not benign, and considering their ages, comorbidities and high rate of mortalities, appropriate interventions and close follow-up for this age group are needed.

Evaluation of mortality, disease activity, treatment, clinical and immunological features of adult and late onset systemic Lupus erythematosus

Death in late onset SLE occurred in 7.5% of patients and it was associated with sicca symptoms, and the use of HCQ and LDA is positively correlated with survival.

Cardiac tamponade as the first manifestation of systemic lupus erythematosus in the elderly.

A 91-year-old woman diagnosed with cardiac tamponade, which was the presenting clinical feature of a previously undiagnosed case of systemic lupus erythematosus, is reported.

The Neurosyphilitic Psychoses Today

  • K. Dewhurst
  • Medicine, Psychology
    British Journal of Psychiatry
  • 1969
The widespread use of antibiotics, though greatly reducing the incidence of neurosyphilitic psychosis, may well have increased the mutability of the disease as reflected in its changing prevalence, distribution and clinical characteristics.

Penicillin Treatment of General Paresis (Dementia Paralytica): Results of Treatment in 1,086 Patients the Majority of Whom Were Followed for More Than Five Years

A cooperative report of the clinical, spinal fluid, and serologic findings in a group of 1,086 patients with general paresis treated with penicillin with or without fever therapy at eight different hospitals.

Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus.

  • M. Hochberg
  • Medicine, Biology
    Arthritis and rheumatism
  • 1997
In 1992, Piette and colleagues suggested that the ACR revised criteria be reevaluated in light of the above discoveries, and the presence and clinical associations or antiphospholipid antibodies in patients with SLE was suggested.