Neurosurgery for schizophrenia: an update on pathophysiology and a novel therapeutic target.

  title={Neurosurgery for schizophrenia: an update on pathophysiology and a novel therapeutic target.},
  author={Charles B. Mikell and Saurabh R. Sinha and Sameer A. Sheth},
  journal={Journal of neurosurgery},
  volume={124 4},
The main objectives of this review were to provide an update on the progress made in understanding specific circuit abnormalities leading to psychotic symptoms in schizophrenia and to propose rational targets for therapeutic deep brain stimulation (DBS). Refractory schizophrenia remains a major unsolved clinical problem, with 10%-30% of patients not responding to standard treatment options. Progress made over the last decade was analyzed through reviewing structural and functional neuroimaging… CONTINUE READING


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