Neurostimulation in the treatment of epilepsy

@article{Bergey2013NeurostimulationIT,
  title={Neurostimulation in the treatment of epilepsy},
  author={G. Bergey},
  journal={Experimental Neurology},
  year={2013},
  volume={244},
  pages={87-95}
}
  • G. Bergey
  • Published 2013
  • Medicine
  • Experimental Neurology
There is increased interest in neurostimulation as a treatment for drug-resistant epilepsy. Two large pivotal trials have recently been completed, one using bilateral anterior thalamic stimulation and another employing closed loop responsive therapy of the brain. These are potential additions to the therapeutic options for neurostimulation in addition to already approved vagus nerve stimulation. This review will address the principles of the various types of neurostimulation, the results of the… Expand
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References

SHOWING 1-10 OF 74 REFERENCES
Transcranial Magnetic Stimulation for Drug-Resistant Epilepsies: Rationale and Clinical Experience
TLDR
It is concluded that, although the therapeutic effects of repetitive TMS in epilepsy appear rather limited, further clinical testing of this rapidly evolving technology is warranted. Expand
Electrical Stimulation of the Anterior Nucleus of the Thalamus for the Treatment of Intractable Epilepsy
TLDR
An open‐label pilot study is embarked on to determine initial safety and tolerability of bilateral stimulation of the anterior nucleus of the thalamus (ANT), to determine a range of appropriate stimulation parameters, and to begin to gather pilot efficacy data. Expand
Neurostimulation therapies for treatment resistant depression: A focus on vagus nerve stimulation and deep brain stimulation
TLDR
VNS and deep brain stimulation are neurostimulation treatments for TRD and the evidence supporting the clinical utility of these therapies is reviewed. Expand
Deep brain stimulation in epilepsy with particular reference to the subthalamic nucleus.
Alternative methods, for the treatment of medically refractory epileptic patients, who cannot be treated by resective surgery, such as chronic deep brain neurostimulation, are under development. SuchExpand
Responsive cortical stimulation for the treatment of medically intractable partial epilepsy
TLDR
This study provides Class I evidence that responsive cortical stimulation is effective in significantly reducing seizure frequency for 12 weeks in adults who have failed 2 or more antiepileptic medication trials, 3 or more seizures per month, and 1 or 2 seizure foci. Expand
Acute and long-term safety of external trigeminal nerve stimulation for drug-resistant epilepsy
TLDR
The data indicate that eTNS of the infraorbital and supraorbital branches of the trigeminal nerve is safe and well tolerated. Expand
TRIGEMINAL NERVE STIMULATION FOR EPILEPSY: LONG-TERM FEASIBILITY AND EFFICACY
TLDR
The long-term safety and efficacy of external TNS for epilepsy, a novel form of neurostimulation that has an antiepileptic effect in a rodent model, is reported. Expand
Noninvasive brain stimulation protocols in the treatment of epilepsy: Current state and perspectives
TLDR
In animal models, stimulation-induced cortical excitability diminution has been shown to be suited to reduce seizures and reasons for this, as well as possible optimization strategies that might lead to more efficient future stimulation protocols, will be discussed. Expand
A double-blind trial of chronic cerebellar stimulation in twelve patients with severe epilepsy.
TLDR
Cerebellar stimulation in its present form cannot be recommended for the treatment of severe intractable epilepsy, though eleven of the patients considered that the trial had helped them. Expand
Randomized controlled trial of trigeminal nerve stimulation for drug-resistant epilepsy
TLDR
This phase II study provides Class II evidence that trigeminal nerve stimulation may be safe and effective in reducing seizures in people with DRE and will serve as a basis to inform and power a larger multicenter phase III clinical trial. Expand
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