Neurostimulation for the Treatment of Epilepsy: A Review of Current Surgical Interventions

@article{Wu2013NeurostimulationFT,
  title={Neurostimulation for the Treatment of Epilepsy: A Review of Current Surgical Interventions},
  author={Chengyuan Wu and Ashwini D Sharan},
  journal={Neuromodulation: Technology at the Neural Interface},
  year={2013},
  volume={16}
}
Objectives:  Epilepsy continues to provide challenges to clinicians, as a significant proportion of patients continue to suffer from seizures despite medical and surgical treatments. Neurostimulation has emerged as a new treatment modality that has the potential to improve quality of life and occasionally be curative for patients with medically refractory epilepsy who are not surgical candidates. In order to continue to advance the frontier of this field, it is imperative to have a firm grasp… 
Surgical Treatment of Epilepsy : The Cutting Edge
TLDR
Surgical outcomes in extratemporal lobe epilepsy and nonlesional epilepsy still have room for improvement using various approaches and palliative procedures and neuromodulation therapies are available for these ‘ truly intractable epilepsy cases ’ at present.
Neurostimulation. A promising therapeutic option for medically refractory epilepsy.
TLDR
Vagus nerve stimulation, deep brain stimulation of the anterior nucleus of thalamus, and responsive neurostimulation have class I evidence supporting their use in patients with intractable epilepsy, and their application in clinical use is discussed.
Surgical Considerations in the Management of Epilepsy
TLDR
The process of presurgical evaluation is summarised, followed by an overview of current surgical treatments available, and there is great Surgical Considerations in the Management of Epilepsy.
Neurostimulation for drug-resistant epilepsy
TLDR
In an effort to improve the quality of life for these remaining patients, both epileptologists and neurosurgeons have been turning to the use of neuromodulation – the therapeutic application of electric currents to the nervous system.
Advances in epilepsy surgery
This review summarises exciting recent and forthcoming advances that will impact on the surgical management of epilepsy in the near future. This does not cover the current accepted diagnostic
Neuromodulation in Drug Resistant Epilepsy
TLDR
The evidence, indications and safety considerations for the neuromodulation therapies in vagal nerve stimulation (VNS), responsive neurostimulation (RNS), or deep brain stimulation (DBS) are presented.
Epilepsy Surgery: Current Status and Ongoing Challenges
  • K. Kawai
  • Medicine
    Neurologia medico-chirurgica
  • 2015
TLDR
Surgical outcome of resective surgery for focal seizures associated with focal lesions is satisfactory, but surgical outcome in nonlesional extratemporal lobe epilepsy is still to be improved using various approaches.
Neuromodulation in Pediatric Epilepsy.
Epilepsy and Deep Brain Stimulation of Anterior Thalamic Nucleus
TLDR
New technological advances in DBS technology are expected to positively impact the treatment options of patients with drug-resistant epilepsy, which is associated with severe disability and morbidity.
...
...

References

SHOWING 1-10 OF 214 REFERENCES
Chronic Anterior Thalamus Stimulation for Intractable Epilepsy
Summary:  Purpose: A significant number of patients with epilepsy remain poorly controlled despite antiepileptic medication (AED) treatment and are not eligible for resective surgery. Novel
Electrical stimulation for the treatment of epilepsy
Alternative Surgical Approaches in Epilepsy
TLDR
Results from the SANTE (Stimulation of the Anterior Nuclei of Thalamus for Epilepsy) trial demonstrate a significant reduction in seizure frequency with programmed stimulation, and the RNS™ System (NeuroPace, Mountain View, CA), which uses a closed-loop system termed responsive neurostimulation to both detect apparent seizure onsets and deliver stimulation, demonstrates a sustained reduction in seizures frequency.
Neuromodulation in Epilepsy
TLDR
The current strategies and future applications of neuromodulation in epilepsy are reviewed and novel therapeutic methods that may open new horizons in the management of epilepsy include transcranial magnetic stimulation, focal drug delivery, cellular transplantation, and gene therapy.
Experimental electrical stimulation therapy for epilepsy
TLDR
Control trials are in progress for intermittent cycling stimulation of the anterior nuclei of the thalamus, and for corti-cal stimulation at a seizure focus, responsive to detection of seizure onset.
Anterior thalamic nucleus stimulation for epilepsy.
TLDR
The prospective double-blind randomized Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy (SANTE) trial will evaluate the efficacy of this technique for epilepsy treatment.
Responsive cortical stimulation for the treatment of epilepsy
Neurostimulation for epilepsy.
...
...