Neurosteroids regulate mouse aggression induced by anabolic androgenic steroids

@article{Pibiri2006NeurosteroidsRM,
  title={Neurosteroids regulate mouse aggression induced by anabolic androgenic steroids},
  author={F. Pibiri and M. Nelson and G. Carboni and G. Pinna},
  journal={NeuroReport},
  year={2006},
  volume={17},
  pages={1537-1541}
}
Anabolic androgenic steroid abuse triggers impulsive aggression, anxiety, and depression, which suggests a dysfunction of GABAergic neurotransmission. Socially isolated female mice that have received testosterone propionate (1.45 μmol/kg) treatment for 3 weeks during social isolation express aggression, neurosteroid downregulation, and changes in the cortical mRNA expression of several &ggr;-aminobutyric acid type A receptor subunits (&agr;1, &agr;2, &ggr;2 are decreased by 30–40%, and &agr;4… Expand
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