Neurosteroids and potential therapeutics: Focus on pregnenolone

@article{Valle2016NeurosteroidsAP,
  title={Neurosteroids and potential therapeutics: Focus on pregnenolone},
  author={Monique Vall{\'e}e},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2016},
  volume={160},
  pages={78-87}
}
  • M. Vallée
  • Published 1 June 2016
  • Medicine, Biology
  • The Journal of Steroid Biochemistry and Molecular Biology
Considerable evidence from preclinical and clinical studies shows that steroids and in particular neurosteroids are important endogenous modulators of several brain-related functions. In this context, it remains to be elucidated whether neurosteroids may serve as biomarkers in the diagnosis of disorders and might have therapeutic potential for the treatment of these disorders. Pregnenolone (PREG) is the main steroid synthesized from cholesterol in mammals and invertebrates. PREG has three main… Expand
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