Neurosteroids and potential therapeutics: Focus on pregnenolone
@article{Valle2016NeurosteroidsAP, title={Neurosteroids and potential therapeutics: Focus on pregnenolone}, author={Monique Vall{\'e}e}, journal={The Journal of Steroid Biochemistry and Molecular Biology}, year={2016}, volume={160}, pages={78-87} }
51 Citations
The neurosteroid pregnenolone promotes degradation of key proteins in the innate immune signaling to suppress inflammation
- Biology, MedicineThe Journal of Biological Chemistry
- 2019
Experimental data reveal novel nongenomic targets of pregnenolone and provide important leads to understand its role in restoring immune homeostasis in various inflammatory conditions.
New perspectives on the role of the neurosteroid pregnenolone as an endogenous regulator of type‐1 cannabinoid receptor (CB1R) activity and function
- Biology, MedicineJournal of neuroendocrinology
- 2021
The action of pregnenolone is described as a negative allosteric modulator and a specific signalling inhibitor of the CB1R, which provides a great strategic opportunity for therapeutic development in CB1‐related disorders.
Therapeutic potential of pregnenolone and pregnenolone methyl ether on depressive and CDKL5 deficiency disorders: Focus on microtubule targeting
- BiologyJournal of neuroendocrinology
- 2021
The beneficial effect of PME is described in major depressive disorders (MDDs) and in CDKL5 deficiency disorder (CDD), two pathologies that are joint by defective MT dynamics.
Precise and accurate assay of pregnenolone and five other neurosteroids in monkey brain tissue by LC–MS/MS
- Biology, ChemistrySteroids
- 2016
Stress and drug abuse-related disorders: The promising therapeutic value of neurosteroids focus on pregnenolone-progesterone-allopregnanolone pathway
- Medicine, BiologyFrontiers in Neuroendocrinology
- 2019
Development and validation of a quantitative proton NMR method for the analysis of pregnenolone.
- BiologyJournal of pharmaceutical and biomedical analysis
- 2022
A simple and rapid quantitative proton nuclear magnetic resonance spectroscopy (qNMR) method for the identification and assay of PREg in different types of PREG products was developed and validated and demonstrates the potential of qNMR for the quality assessment of different typesof PREG samples.
Neurosteroid biosynthesis down‐regulation and changes in GABAA receptor subunit composition: a biomarker axis in stress‐induced cognitive and emotional impairment
- BiologyBritish journal of pharmacology
- 2017
Current knowledge on the effects of stress on neurosteroid biosynthesis and GABAA receptor neurotransmission are described and available pharmacological strategies that by enhancing neurosteroidsogenesis are relevant for the treatment of SSRI‐resistant patients are summarized.
Choosing the right drug: status and future of endocannabinoid research for the prevention of drug-seeking reinstatement.
- Biology, MedicineCurrent opinion in pharmacology
- 2020
Comparative Untargeted Metabolomics Analysis of the Psychostimulants 3,4-Methylenedioxy-Methamphetamine (MDMA), Amphetamine, and the Novel Psychoactive Substance Mephedrone after Controlled Drug Administration to Humans
- BiologyMetabolites
- 2020
Overall, mephedrone produced a profile more similar to that of amphetamine than MDMA in terms of affected energy metabolism, which can provide the basis for further in-depth targeted metabolome studies on pharmacological actions and search for biomarkers of drug use.
Pregnenolone blocks cannabinoid-induced acute psychotic-like states in mice
- Psychology, BiologyMolecular Psychiatry
- 2017
Test in mice the potential therapeutic use of pregnenolone against acute psychotic-like effects of Δ9-tetrahydrocannabinol, the main psychoactive component of cannabis found that it blocks a wide spectrum of THC-induced endophenotypes typically associated with psychotic- like states, including impairments in cognitive functions, somatosensory gating and social interaction.
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