Neurosteroids and female reproduction: estrogen increases 3beta-HSD mRNA and activity in rat hypothalamus.

@article{Soma2005NeurosteroidsAF,
  title={Neurosteroids and female reproduction: estrogen increases 3beta-HSD mRNA and activity in rat hypothalamus.},
  author={Kiran K. Soma and Kevin Sinchak and Alexander J. Lakhter and Barney A Schlinger and Paul E Micevych},
  journal={Endocrinology},
  year={2005},
  volume={146 10},
  pages={4386-90}
}
A central event in mammalian reproduction is the LH surge that induces ovulation and corpus luteum formation. Typically, the LH surge is initiated in ovariectomized rats by sequential treatment with estrogen and progesterone (PROG). The traditional explanation for this paradigm is that estrogen induces PROG receptors (PR) that are activated by exogenous PROG. Recent evidence suggests that whereas exogenous estrogen is necessary, exogenous PROG is not. In ovariectomized-adrenalectomized rats… CONTINUE READING

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Estrogen induces progesterone synthesis in hypothalamic astrocytes through an increase of intracellular calcium levels

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