Neurosteroids and Microneurotrophins Signal Through NGF Receptors to Induce Prosurvival Signaling in Neuronal Cells

@article{Gravanis2012NeurosteroidsAM,
  title={Neurosteroids and Microneurotrophins Signal Through NGF Receptors to Induce Prosurvival Signaling in Neuronal Cells},
  author={Achilleas Gravanis and Theodora Calogeropoulou and Vily Panoutsakopoulou and Kyriaki Thermos and Constantinos Neophytou and Ioannis Charalampopoulos},
  journal={Science Signaling},
  year={2012},
  volume={5},
  pages={pt8 - pt8}
}
Synthetic DHEA analogs promote neuronal survival without estrogenic or androgenic side effects. The neurosteroid dehydroepiandrosterone (DHEA) exerts a portion of its neuroprotective effects by directly interacting with the nerve growth factor (NGF) receptors TrkA and p75NTR to induce prosurvival signaling. DHEA is an intermediate in the biosynthesis of estrogens and androgens that affects the endocrine system and potentially increases the risk for developing estrogen- and androgen-dependent… 
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