• DOI:10.1126/scisignal.2003387
Corpus ID: 26914550

Neurosteroids and Microneurotrophins Signal Through NGF Receptors to Induce Prosurvival Signaling in Neuronal Cells

@article{Gravanis2012NeurosteroidsAM,
  title={Neurosteroids and Microneurotrophins Signal Through NGF Receptors to Induce Prosurvival Signaling in Neuronal Cells},
  author={Achille G. Gravanis and Theodora Calogeropoulou and Vily Panoutsakopoulou and Kyriaki Thermos and Constantinos Neophytou and Ioannis Charalampopoulos},
  journal={Science Signaling},
  year={2012},
  volume={5},
  pages={pt8 - pt8}
}

Achille G. Gravanis, Theodora Calogeropoulou, +3 authors Ioannis Charalampopoulos

Published 2012

Medicine, Biology

Science Signaling

Synthetic DHEA analogs promote neuronal survival without estrogenic or androgenic side effects. The neurosteroid dehydroepiandrosterone (DHEA) exerts a portion of its neuroprotective effects by directly interacting with the nerve growth factor (NGF) receptors TrkA and p75NTR to induce prosurvival signaling. DHEA is an intermediate in the biosynthesis of estrogens and androgens that affects the endocrine system and potentially increases the risk for developing estrogen- and androgen-dependent… CONTINUE READING

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