• DOI:10.1016/0896-6273(90)90202-Q
Corpus ID: 12626366

Neurosteroids act on recombinant human GABAA receptors

@article{Puia1990NeurosteroidsAO,
  title={Neurosteroids act on recombinant human GABAA receptors},
  author={G. Puia and M. Santi and S. Vicini and D. Pritchett and E. Costa},
  journal={Neuron},
  year={1990},
  volume={4},
  pages={759-765}
}

G. Puia, M. Santi, +2 authors E. Costa

Published 1990

Chemistry, Medicine

Neuron

The endogenous steroid metabolites 3 alpha,21dihydroxy-5 alpha-pregnan-20-one and 3 alpha-hydroxy-5 alpha-pregnan-20-one potentiate GABA-activated Cl- currents recorded from a human cell line transfected with the beta 1, alpha 1 beta 1, and alpha 1 beta 1 gamma 2 combinations of human GABAA receptor subunits. These steroids are active at nanomolar concentrations in potentiating GABA-activated Cl- currents and directly elicit bicuculline-sensitive Cl- currents when applied at micromolar… CONTINUE READING

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