Neurosteroids act on recombinant human GABAA receptors
@article{Puia1990NeurosteroidsAO, title={Neurosteroids act on recombinant human GABAA receptors}, author={G. Puia and M. Santi and S. Vicini and D. Pritchett and E. Costa}, journal={Neuron}, year={1990}, volume={4}, pages={759-765} }
The endogenous steroid metabolites 3 alpha,21dihydroxy-5 alpha-pregnan-20-one and 3 alpha-hydroxy-5 alpha-pregnan-20-one potentiate GABA-activated Cl- currents recorded from a human cell line transfected with the beta 1, alpha 1 beta 1, and alpha 1 beta 1 gamma 2 combinations of human GABAA receptor subunits. These steroids are active at nanomolar concentrations in potentiating GABA-activated Cl- currents and directly elicit bicuculline-sensitive Cl- currents when applied at micromolar… CONTINUE READING
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