Neurosteroids Modulate Nicotinic Receptor Function in Mouse Striatal and Thalamic Synaptosomes

@article{Bullock1997NeurosteroidsMN,
  title={Neurosteroids Modulate Nicotinic Receptor Function in Mouse Striatal and Thalamic Synaptosomes},
  author={Amy E. Bullock and Amy L. Clark and Sharon R. Grady and Scott F. Robinson and B S Slobe and Michael J. Marks and Allan C. Collins},
  journal={Journal of Neurochemistry},
  year={1997},
  volume={68}
}
Abstract: Progesterone and its A‐ring reduced metabolites are allosteric activators of GABAA receptors. The studies reported here examined the effects of these steroids on brain nicotinic receptors using an 86Rb+ efflux assay that likely measures the function of α4β2‐type nicotinic receptors and [3H]dopamine release, which may be modulated by an α3‐containing nicotinic receptor. Both of the A‐ring reduced metabolites of progesterone were noncompetitive inhibitors of both assays, whereas… Expand
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