author={Eduardo E. Benarroch},
  pages={945 - 947}

From Cannabinoids and Neurosteroids to Statins and the Ketogenic Diet: New Therapeutic Avenues in Rett Syndrome?

Some of the newest evidence on RTT clinical and preclinical research are focused on, evaluating their impact in RTT symptomatology control, and pinpointing possible directions for future research.

Neuroactive steroid levels and psychiatric and andrological features in post-finasteride patients

A history of previous childbirths is linked to women's white matter brain age in midlife and older age

While the findings demonstrate a link between reproductive history and brain WM characteristics later in life, longitudinal studies are required to establish causality and determine how parity may influence women’s WM trajectories across the lifespan.

Women with a history of previous childbirths show less evident white matter brain ageing

The results showed that a higher number of previous childbirths was associated with lower WM brain age, in line with previous studies showing less evident grey matter (GM) brain ageing in parous relative to nulliparous women.

Neurosteroids and Seizure Activity

Initial clinical data indicate that ganaxolone may provide a better seizure control in patients with drug-resistant epilepsy, and its use may also prove efficient for the management of neonatal seizures associated with hypoxic injury.

Chronic Antipsychotic Treatment Modulates Aromatase (CYP19A1) Expression in the Male Rat Brain

Both clozapine and haloperidol treatment, but not olanzapine treatment, led to an increase of aromatase mRNA expression in the rat brain and protein level remained unchanged after drug administration, which underlines the complex nature of potential interactions between neuroleptic pharmacological effects and physiology of brain neurosteroid pathways.

The Phytoestrogen Genistein Produces Similar Effects as 17β-Estradiol on Anxiety-Like Behavior in Rats at 12 Weeks after Ovariectomy

The phytoestrogen genistein has potential for reducing anxiety-like behavior associated with low concentrations of ovarian hormones, which normally occurs during natural and surgical menopause.

New steps forward in the neuroactive steroid field