• DOI:10.1038/nrn1703
Corpus ID: 12596378

Neurosteroids: endogenous regulators of the GABAA receptor

@article{Belelli2005NeurosteroidsER,
  title={Neurosteroids: endogenous regulators of the GABAA receptor},
  author={D. Belelli and J. Lambert},
  journal={Nature Reviews Neuroscience},
  year={2005},
  volume={6},
  pages={565-575}
}

D. Belelli, J. Lambert

Published 2005

Chemistry, Medicine

Nature Reviews Neuroscience

GABAA (γ-aminobutyric acid type A) receptors mediate most of the 'fast' synaptic inhibition in the mammalian brain and are targeted by many clinically important drugs. Certain naturally occurring pregnane steroids can potently and specifically enhance GABAA receptor function in a nongenomic (direct) manner, and consequently have anxiolytic, analgesic, anticonvulsant, sedative, hypnotic and anaesthetic properties. These steroids not only act as remote endocrine messengers, but also can be… CONTINUE READING

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