Neurosteroids: endogenous regulators of the GABAA receptor

  title={Neurosteroids: endogenous regulators of the GABAA receptor},
  author={D. Belelli and J. Lambert},
  journal={Nature Reviews Neuroscience},
  • D. Belelli, J. Lambert
  • Published 2005
  • Chemistry, Medicine
  • Nature Reviews Neuroscience
  • GABAA (γ-aminobutyric acid type A) receptors mediate most of the 'fast' synaptic inhibition in the mammalian brain and are targeted by many clinically important drugs. Certain naturally occurring pregnane steroids can potently and specifically enhance GABAA receptor function in a nongenomic (direct) manner, and consequently have anxiolytic, analgesic, anticonvulsant, sedative, hypnotic and anaesthetic properties. These steroids not only act as remote endocrine messengers, but also can be… CONTINUE READING
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