Neurosteroids: endogenous regulators of the GABAA receptor

@article{Belelli2005NeurosteroidsER,
  title={Neurosteroids: endogenous regulators of the GABAA receptor},
  author={D. Belelli and J. Lambert},
  journal={Nature Reviews Neuroscience},
  year={2005},
  volume={6},
  pages={565-575}
}
  • D. Belelli, J. Lambert
  • Published 2005
  • Chemistry, Medicine
  • Nature Reviews Neuroscience
  • GABAA (γ-aminobutyric acid type A) receptors mediate most of the 'fast' synaptic inhibition in the mammalian brain and are targeted by many clinically important drugs. Certain naturally occurring pregnane steroids can potently and specifically enhance GABAA receptor function in a nongenomic (direct) manner, and consequently have anxiolytic, analgesic, anticonvulsant, sedative, hypnotic and anaesthetic properties. These steroids not only act as remote endocrine messengers, but also can be… CONTINUE READING
    943 Citations

    Figures and Topics from this paper

    Explore Further: Topics Discussed in This Paper

    Neurosteroid modulation of synaptic and extrasynaptic GABA(A) receptors.
    • 185
    Mechanisms of neurosteroid interactions with GABA(A) receptors.
    • 125
    The sticky issue of neurosteroids and GABAA receptors
    • 86
    Neurosteroids: Endogenous allosteric modulators of GABAA receptors
    • 147
    Extrasynaptic GABAA receptors in the crosshairs of hormones and ethanol
    • I. Módy
    • Biology, Medicine
    • Neurochemistry International
    • 2008
    • 36
    Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor
    • 9
    GABA Receptors: Pharmacological Potential and Pitfalls.
    • 43
    • Highly Influenced
    • PDF

    References

    SHOWING 1-10 OF 140 REFERENCES
    Neurosteroids and GABAA receptor function.
    • 698
    Neurosteroid modulation of GABAA receptors
    • 449
    Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by δ subunit-containing GABAA receptors
    • 732
    • PDF
    Neuroactive steroids: mechanisms of action and neuropsychopharmacological properties
    • 400
    Attenuated sensitivity to neuroactive steroids in gamma-aminobutyrate type A receptor delta subunit knockout mice.
    • 497
    • PDF
    Slow Actions of Neuroactive Steroids at GABAA Receptors
    • 104
    • PDF