Neurosteroids: biochemistry and clinical significance

@article{Mellon2002NeurosteroidsBA,
  title={Neurosteroids: biochemistry and clinical significance},
  author={Synthia H Mellon and Lisa D. Griffin},
  journal={Trends in Endocrinology \& Metabolism},
  year={2002},
  volume={13},
  pages={35-43}
}
  • S. MellonL. D. Griffin
  • Published 1 January 2002
  • Biology, Medicine, Chemistry
  • Trends in Endocrinology & Metabolism
View on Elsevier
doi.org
480 Citations
Highly Influential Citations
26
Background Citations
186
Methods Citations
5

480 Citations

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  • R. Guennoun
  • Biology, Medicine
    International journal of molecular sciences
  • 2020
The biosynthetic pathways and the expression of enzymes and receptors of progesterone; as well as the changes observed after brain injuries and in neurological diseases; and the key role of the classical progester one receptors (PR) in mediating the neuroprotective effects of progestersone after stroke are highlighted.

Neurosteroidogenic enzymes: CYP11A1 in the central nervous system

Neurosteroid Metabolites of Gonadal Steroid Hormones in Neuroprotection: Implications for Sex Differences in Neurodegenerative Disease

The hypothesis that differences between males and females in local neurosteroid production may contribute to sex differences in the development of neurodegenerative disease is explored.

Neurosteroid modulation of synaptic and extrasynaptic GABA(A) receptors.

Steroid Biosynthesis within the Frog Brain

Data indicate that some of the neurophysiological effects of neurotransmitters and neuropeptides may be mediated through modulation of neurosteroid biosynthesis.

Revisiting the roles of progesterone and allopregnanolone in the nervous system: Resurgence of the progesterone receptors

Nongenomic actions of neurosteroid pregnenolone and its metabolites

...

References

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Neurosteroids: Biosynthesis and Function of These Novel Neuromodulators

This paper summarizes what is known about the biosynthesis of neurosteroids, the enzymes mediating these reactions, their localization during development and in the adult, and their function and mechanisms of action in the developing and adult central and peripheral nervous systems.

NEUROSTEROIDS: A NOVEL FUNCTION OF THE BRAIN

  • E. Baulieu
  • Biology, Medicine
    Psychoneuroendocrinology
  • 1998

Expression of the steroidogenic enzyme P450scc in the central and peripheral nervous systems during rodent embryogenesis.

It is demonstrated that P450scc is expressed in the nervous system of the developing rodent embryo in cell lineages derived from the neural crest and the sites of expression are located mainly in sensory structures of the peripheral nervous system during embryogenesis, suggesting a possible function in coordinating environmental cues and behavior and in the development and organization of the nervous System.

Steroidogenic enzyme P450c17 is expressed in the embryonic central nervous system.

It is demonstrated that P450c17 is expressed in the nervous system of the developing rodent embryo, suggesting it is a marker for the axonal growth in this region, and that its neurosteroid product may be a signal for targeting cortical axons during embryogenesis.

Neurosteroids : a new regulatory function in the nervous system

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Modulation of steroidal levels by adrenalectomy/castration and inhibition of neurosteroid synthesis enzymes affect σ1 receptor‐mediated behaviour in mice

Investigation of the effects of inhibitors of key enzymes involved in neurosteroid synthesis in adrenalectomized/castrated mice revealed that, among neurosteroids, progesterone may be the main modulator of σ1 receptors.
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