Neurosteroids: biochemistry and clinical significance

  title={Neurosteroids: biochemistry and clinical significance},
  author={Synthia H Mellon and Lisa D. Griffin},
  journal={Trends in Endocrinology \& Metabolism},
  • S. MellonL. D. Griffin
  • Published 1 January 2002
  • Biology, Medicine, Chemistry
  • Trends in Endocrinology & Metabolism

Neurosteroids: Endogenous modulators of neuronal excitability and plasticity

Steroidogenesis in the nervous system is regulated by interactions between neurons and glial cells, and drugs that affect synthesis or metabolism of neurosteroids provide a new therapeutic opportunity for treatment of these disorders.

Regulation of Neurosteroid Biosynthesis by Neurotransmitters and Neuropeptides

It has been found that glutamate, acting through kainate and/or AMPA receptors, rapidly inactivates P450arom, and that melatonin production by the pineal gland and eye inhibits the biosynthesis of 7α-hydroxypregnenolone, while prolactin produced by the adenohypophysis enhances the formation of 7 α-OH-Δ5P.

Progesterone in the Brain: Hormone, Neurosteroid and Neuroprotectant

  • R. Guennoun
  • Biology, Medicine
    International journal of molecular sciences
  • 2020
The biosynthetic pathways and the expression of enzymes and receptors of progesterone; as well as the changes observed after brain injuries and in neurological diseases; and the key role of the classical progester one receptors (PR) in mediating the neuroprotective effects of progestersone after stroke are highlighted.

Neurosteroidogenic enzymes: CYP11A1 in the central nervous system

Neurosteroid Metabolites of Gonadal Steroid Hormones in Neuroprotection: Implications for Sex Differences in Neurodegenerative Disease

The hypothesis that differences between males and females in local neurosteroid production may contribute to sex differences in the development of neurodegenerative disease is explored.

Steroid Biosynthesis within the Frog Brain

Data indicate that some of the neurophysiological effects of neurotransmitters and neuropeptides may be mediated through modulation of neurosteroid biosynthesis.



Neurosteroids: Biosynthesis and Function of These Novel Neuromodulators

This paper summarizes what is known about the biosynthesis of neurosteroids, the enzymes mediating these reactions, their localization during development and in the adult, and their function and mechanisms of action in the developing and adult central and peripheral nervous systems.


  • E. Baulieu
  • Biology, Medicine
  • 1998

Expression of the steroidogenic enzyme P450scc in the central and peripheral nervous systems during rodent embryogenesis.

It is demonstrated that P450scc is expressed in the nervous system of the developing rodent embryo in cell lineages derived from the neural crest and the sites of expression are located mainly in sensory structures of the peripheral nervous system during embryogenesis, suggesting a possible function in coordinating environmental cues and behavior and in the development and organization of the nervous System.

Steroidogenic enzyme P450c17 is expressed in the embryonic central nervous system.

It is demonstrated that P450c17 is expressed in the nervous system of the developing rodent embryo, suggesting it is a marker for the axonal growth in this region, and that its neurosteroid product may be a signal for targeting cortical axons during embryogenesis.

Neurosteroids : a new regulatory function in the nervous system

Neurosteroids: From Definition and Biochemistry to Physiopathologic Function, Paul Robel, Michael Schumacher, and Etienne-Emile Baulieu. Molecular Biology and Developmental Regulation of the Enzymes

Neurosteroids: expression of steroidogenic enzymes and regulation of steroid biosynthesis in the central nervous system.

Steroid hormones, which are synthesized in the adrenal gland, gonads and placenta, exert a large array of biological effects on the nervous system, including development, growth, maturation, and differentiation of the central nervous system.

Modulation of steroidal levels by adrenalectomy/castration and inhibition of neurosteroid synthesis enzymes affect σ1 receptor‐mediated behaviour in mice

Investigation of the effects of inhibitors of key enzymes involved in neurosteroid synthesis in adrenalectomized/castrated mice revealed that, among neurosteroids, progesterone may be the main modulator of σ1 receptors.