Neurosteroid biosynthesis: Enzymatic pathways and neuroendocrine regulation by neurotransmitters and neuropeptides
- Biology, PsychologyFrontiers in Neuroendocrinology
Neurosteroids: Endogenous modulators of neuronal excitability and plasticity
- Biology, MedicineNeurology
Steroidogenesis in the nervous system is regulated by interactions between neurons and glial cells, and drugs that affect synthesis or metabolism of neurosteroids provide a new therapeutic opportunity for treatment of these disorders.
Regulation of Neurosteroid Biosynthesis by Neurotransmitters and Neuropeptides
- BiologyFront. Endocrin.
It has been found that glutamate, acting through kainate and/or AMPA receptors, rapidly inactivates P450arom, and that melatonin production by the pineal gland and eye inhibits the biosynthesis of 7α-hydroxypregnenolone, while prolactin produced by the adenohypophysis enhances the formation of 7 α-OH-Δ5P.
Progesterone in the Brain: Hormone, Neurosteroid and Neuroprotectant
- Biology, MedicineInternational journal of molecular sciences
The biosynthetic pathways and the expression of enzymes and receptors of progesterone; as well as the changes observed after brain injuries and in neurological diseases; and the key role of the classical progester one receptors (PR) in mediating the neuroprotective effects of progestersone after stroke are highlighted.
Neurosteroidogenic enzymes: CYP11A1 in the central nervous system
- Biology, MedicineFrontiers in Neuroendocrinology
Neurosteroid Metabolites of Gonadal Steroid Hormones in Neuroprotection: Implications for Sex Differences in Neurodegenerative Disease
- Biology, MedicineFront. Mol. Neurosci.
The hypothesis that differences between males and females in local neurosteroid production may contribute to sex differences in the development of neurodegenerative disease is explored.
Neurosteroid modulation of synaptic and extrasynaptic GABA(A) receptors.
- Biology, MedicinePharmacology & therapeutics
Steroid Biosynthesis within the Frog Brain
- Biology, ChemistryAnnals of the New York Academy of Sciences
Data indicate that some of the neurophysiological effects of neurotransmitters and neuropeptides may be mediated through modulation of neurosteroid biosynthesis.
Revisiting the roles of progesterone and allopregnanolone in the nervous system: Resurgence of the progesterone receptors
- Biology, MedicineProgress in Neurobiology
Nongenomic actions of neurosteroid pregnenolone and its metabolites
- Biology, MedicineSteroids
SHOWING 1-10 OF 92 REFERENCES
Neurosteroids: Biosynthesis and Function of These Novel Neuromodulators
- BiologyFrontiers in Neuroendocrinology
This paper summarizes what is known about the biosynthesis of neurosteroids, the enzymes mediating these reactions, their localization during development and in the adult, and their function and mechanisms of action in the developing and adult central and peripheral nervous systems.
Expression of the steroidogenic enzyme P450scc in the central and peripheral nervous systems during rodent embryogenesis.
It is demonstrated that P450scc is expressed in the nervous system of the developing rodent embryo in cell lineages derived from the neural crest and the sites of expression are located mainly in sensory structures of the peripheral nervous system during embryogenesis, suggesting a possible function in coordinating environmental cues and behavior and in the development and organization of the nervous System.
Steroidogenic enzyme P450c17 is expressed in the embryonic central nervous system.
It is demonstrated that P450c17 is expressed in the nervous system of the developing rodent embryo, suggesting it is a marker for the axonal growth in this region, and that its neurosteroid product may be a signal for targeting cortical axons during embryogenesis.
Neurosteroids : a new regulatory function in the nervous system
Neurosteroids: From Definition and Biochemistry to Physiopathologic Function, Paul Robel, Michael Schumacher, and Etienne-Emile Baulieu. Molecular Biology and Developmental Regulation of the Enzymes…
Neuropsychopharmacological properties of neuroactive steroids
- Biology, MedicineSteroids
Neurosteroids: expression of steroidogenic enzymes and regulation of steroid biosynthesis in the central nervous system.
- Biology, MedicinePharmacological reviews
Steroid hormones, which are synthesized in the adrenal gland, gonads and placenta, exert a large array of biological effects on the nervous system, including development, growth, maturation, and differentiation of the central nervous system.
Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain
- BiologyBrain Research
Modulation of steroidal levels by adrenalectomy/castration and inhibition of neurosteroid synthesis enzymes affect σ1 receptor‐mediated behaviour in mice
- Biology, MedicineThe European journal of neuroscience
Investigation of the effects of inhibitors of key enzymes involved in neurosteroid synthesis in adrenalectomized/castrated mice revealed that, among neurosteroids, progesterone may be the main modulator of σ1 receptors.