Neurosteroids: beginning of the story.

  title={Neurosteroids: beginning of the story.},
  author={Etienne Emile Baulieu and Paul Robel and Michael Schumacher},
  journal={International review of neurobiology},
Neurosteroids are synthetisized in the central and the peripheral nervous system, in glial cells, and also in neurons, from cholesterol or steroidal precursors imported from peripheral sources. They include 3 beta-hydroxy-delta 5-compounds, such as pregnenolone (PREG) and dehydroepiandrosterone, their sulfate esters, and compounds known as reduced metabolites of steroid hormones, such as the tetrahydroderivative of progesterone 3 alpha-hydroxy-5 alpha-pregnan-20-one. These neurosteroids can act… CONTINUE READING


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