Neurosteroid pregnenolone sulfate antagonizes electrophysiological responses to GABA in neurons

@article{Majewska1988NeurosteroidPS,
  title={Neurosteroid pregnenolone sulfate antagonizes electrophysiological responses to GABA in neurons},
  author={Maria Dorota Majewska and J. M. Mienville and Stefano Vicini},
  journal={Neuroscience Letters},
  year={1988},
  volume={90},
  pages={279-284}
}
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263 Citations
Highly Influential Citations
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Results Citations
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263 Citations

The neurosteroid dehydroepiandrosterone sulfate is an allosteric antagonist of the GABAA receptor

Pregnenolone sulfate antagonizes GABAA receptor-mediated currents via a reduction of channel opening frequency

Potentiation of GABA-induced inhibition by 20-hydroxyecdysone, a neurosteroid, in cultured rat cortical neurons.

The results suggest that 20-HE acts on the modulatory site of the GABAA receptor and potentiates GABAergic inhibition in rat cortical neurons.

Competitive inhibition of the glycine-induced current by pregnenolone sulfate in cultured chick spinal cord neurons

Pregnenolone sulfate increases the convulsant potency of N-methyl-D-aspartate in mice.

Neurosteroids and Extrasynaptic GABAA Receptors

The synthesis, action and the activity of neurosteroids on synaptic and extrasynaptic GABAA receptors are reviewed.

A presynaptic action of the neurosteroid pregnenolone sulfate on GABAergic synaptic transmission.

Concentrations of PS, similar to those endogenous in the hippocampus, inhibit GABAergic synaptic transmission by a presynaptic effect and improves the understanding of the physiological function of PS.

Neurosteroid modulation of native and recombinant GABAA receptors

The molecular mechanism of action of such steroids and attempts to define the steroid binding site on the receptor protein are described and the therapeutic potential of such neurosteroids is discussed.

Pregnenolone sulfate modulates glycinergic transmission in rat medullary dorsal horn neurons.

Inhibition by pregnenolone sulphate, a metabolite of the neurosteroid pregnenolone, of voltage-gated sodium channels expressed in Xenopus oocytes.

It is suggested that pregnenolone sulphate, a metabolite of pregnanolone, suppresses the function of Na(v) via increased inactivation, which may contribute to the neuroprotection.
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