Neurosteroid pregnenolone sulfate antagonizes electrophysiological responses to GABA in neurons
@article{Majewska1988NeurosteroidPS, title={Neurosteroid pregnenolone sulfate antagonizes electrophysiological responses to GABA in neurons}, author={Maria Dorota Majewska and J. M. Mienville and Stefano Vicini}, journal={Neuroscience Letters}, year={1988}, volume={90}, pages={279-284} }
263 Citations
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Potentiation of GABA-induced inhibition by 20-hydroxyecdysone, a neurosteroid, in cultured rat cortical neurons.
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The results suggest that 20-HE acts on the modulatory site of the GABAA receptor and potentiates GABAergic inhibition in rat cortical neurons.
Competitive inhibition of the glycine-induced current by pregnenolone sulfate in cultured chick spinal cord neurons
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Pregnenolone sulfate increases the convulsant potency of N-methyl-D-aspartate in mice.
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Neurosteroids and Extrasynaptic GABAA Receptors
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The synthesis, action and the activity of neurosteroids on synaptic and extrasynaptic GABAA receptors are reviewed.
A presynaptic action of the neurosteroid pregnenolone sulfate on GABAergic synaptic transmission.
- BiologyMolecular pharmacology
- 2003
Concentrations of PS, similar to those endogenous in the hippocampus, inhibit GABAergic synaptic transmission by a presynaptic effect and improves the understanding of the physiological function of PS.
Neurosteroid modulation of native and recombinant GABAA receptors
- BiologyCellular and Molecular Neurobiology
- 2005
The molecular mechanism of action of such steroids and attempts to define the steroid binding site on the receptor protein are described and the therapeutic potential of such neurosteroids is discussed.
Pregnenolone sulfate modulates glycinergic transmission in rat medullary dorsal horn neurons.
- BiologyEuropean journal of pharmacology
- 2013
Inhibition by pregnenolone sulphate, a metabolite of the neurosteroid pregnenolone, of voltage-gated sodium channels expressed in Xenopus oocytes.
- Biology, MedicineJournal of pharmacological sciences
- 2012
It is suggested that pregnenolone sulphate, a metabolite of pregnanolone, suppresses the function of Na(v) via increased inactivation, which may contribute to the neuroprotection.
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