Neurosteroid metabolism in the human brain.

  title={Neurosteroid metabolism in the human brain.},
  author={Birgit Stoffel-Wagner},
  journal={European journal of endocrinology},
  volume={145 6},
This review summarizes the current knowledge of the biosynthesis of neurosteroids in the human brain, the enzymes mediating these reactions, their localization and the putative effects of neurosteroids. Molecular biological and biochemical studies have now firmly established the presence of the steroidogenic enzymes cytochrome P450 cholesterol side-chain cleavage (P450SCC), aromatase, 5alpha-reductase, 3alpha-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase in human brain… CONTINUE READING