Neurosteroid dehydroepiandrosterone sulfate enhances spontaneous glutamate release in rat prelimbic cortex through activation of dopamine D1 and sigma-1 receptor.

@article{Dong2007NeurosteroidDS,
  title={Neurosteroid dehydroepiandrosterone sulfate enhances spontaneous glutamate release in rat prelimbic cortex through activation of dopamine D1 and sigma-1 receptor.},
  author={L Dong and Zheng-xiang Cheng and Ying-mei Fu and Ze-Min Wang and Yan-hua Zhu and Jian-li Sun and Yi Dong and Ping Zheng},
  journal={Neuropharmacology},
  year={2007},
  volume={52 3},
  pages={966-74}
}
This paper studied the effect of neurosteroid dehydroepiandrosterone sulfate on spontaneous glutamate release in the prelimbic cortex by using electrophysiological and biochemical methods combined with a pharmacological approach and made some comparisons with those in the hippocampus. The results showed that dehydroepiandrosterone sulfate increased the frequency of miniature excitatory postsynaptic currents in the prelimbic cortex and hippocampus; sigma-1 receptor antagonist partially blocked… CONTINUE READING

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