Neurosteroid binding to the amino terminal and glutamate binding domains of ionotropic glutamate receptors.

@article{Cameron2012NeurosteroidBT,
  title={Neurosteroid binding to the amino terminal and glutamate binding domains of ionotropic glutamate receptors.},
  author={Krasnodara N Cameron and Emily I Bartle and Ryan D. Roark and David G Fanelli and Melissa M. Pham and Beth Pollard and Brian A Borkowski and Sarah J Rhoads and Joon Kim and M{\^o}nica Santos Rocha and Martha A. Kahlson and Melinda Kangala and Lisa Gentile},
  journal={Steroids},
  year={2012},
  volume={77 7},
  pages={774-9}
}
The endogenous neurosteroids, pregnenolone sulfate (PS) and 3α-hydroxy-5β-pregnan-20-one sulfate (PREGAS), have been shown to differentially regulate the ionotropic glutamate receptor (iGluR) family of ligand-gated ion channels. Upon binding to these receptors, PREGAS decreases current flow through the channels. Upon binding to non-NMDA or NMDA receptors containing an GluN2C or GluN2D subunit, PS also decreases current flow through the channels, however, upon binding to NMDA receptors… CONTINUE READING