Neurosteroid Biosynthesis Regulates Sexually Dimorphic Fear and Aggressive Behavior in Mice

@article{Pinna2008NeurosteroidBR,
  title={Neurosteroid Biosynthesis Regulates Sexually Dimorphic Fear and Aggressive Behavior in Mice},
  author={Graziano Pinna and Roberto Carlos Ag{\'i}s-Balboa and Fabio Pibiri and Marianela Nelson and Alessandro Guidotti and Erminio Costa},
  journal={Neurochemical Research},
  year={2008},
  volume={33},
  pages={1990-2007}
}
The neurosteroid allopregnanolone is a potent positive allosteric modulator of GABA action at GABAA receptors. Allopregnanolone is synthesized in the brain from progesterone by the sequential action of 5α-reductase type I (5α-RI) and 3α-hydroxysteroid dehydrogenase (3α-HSD). 5α-RI and 3α-HSD are co-expressed in cortical, hippocampal, and olfactory bulb glutamatergic neurons and in output neurons of the amygdala, thalamus, cerebellum, and striatum. Neither 5α-RI nor 3α-HSD mRNAs is expressed in… 

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