Neurosteroid Biosynthesis Regulates Sexually Dimorphic Fear and Aggressive Behavior in Mice
@article{Pinna2008NeurosteroidBR, title={Neurosteroid Biosynthesis Regulates Sexually Dimorphic Fear and Aggressive Behavior in Mice}, author={Graziano Pinna and Roberto Carlos Ag{\'i}s-Balboa and Fabio Pibiri and Marianela Nelson and Alessandro Guidotti and Erminio Costa}, journal={Neurochemical Research}, year={2008}, volume={33}, pages={1990-2007} }
The neurosteroid allopregnanolone is a potent positive allosteric modulator of GABA action at GABAA receptors. Allopregnanolone is synthesized in the brain from progesterone by the sequential action of 5α-reductase type I (5α-RI) and 3α-hydroxysteroid dehydrogenase (3α-HSD). 5α-RI and 3α-HSD are co-expressed in cortical, hippocampal, and olfactory bulb glutamatergic neurons and in output neurons of the amygdala, thalamus, cerebellum, and striatum. Neither 5α-RI nor 3α-HSD mRNAs is expressed in…
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