Neurosphere formation is an independent predictor of clinical outcome in malignant glioma.

@article{Laks2009NeurosphereFI,
  title={Neurosphere formation is an independent predictor of clinical outcome in malignant glioma.},
  author={Dan Richard Laks and Michael D Masterman-Smith and Koppany Visnyei and Brigitte Ang{\'e}nieux and Nicholas M. Orozco and Ian M Foran and William H. Yong and H V Vinters and L M Liau and Jorge Antonio Lazareff and Paul Mischel and Timothy F. Cloughesy and Steve Horvath and Harley Ian Kornblum},
  journal={Stem cells},
  year={2009},
  volume={27 4},
  pages={980-7}
}
Renewable neurosphere formation in culture is a defining characteristic of certain brain tumor initiating cells. This retrospective study was designed to assess the relationship among neurosphere formation in cultured human glioma, tumorigenic capacity, and patient clinical outcome. Tumor samples were cultured in neurosphere conditions from 32 patients with glioma, including a subpopulation of 15 patients with primary glioblastoma. A subsample of renewable neurosphere cultures was xenografted… CONTINUE READING
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