Neurosphere formation enhances the neurogenic differentiation potential and migratory ability of umbilical cord-mesenchymal stromal cells.

@article{Mukai2016NeurosphereFE,
  title={Neurosphere formation enhances the neurogenic differentiation potential and migratory ability of umbilical cord-mesenchymal stromal cells.},
  author={Takeo Mukai and Tokiko Nagamura-Inoue and Takahisa Shimazu and Yuka Mori and Atsuko Takahashi and Hajime Tsunoda and Satoru Yamaguchi and Arinobu Tojo},
  journal={Cytotherapy},
  year={2016},
  volume={18 2},
  pages={229-41}
}
BACKGROUND AIMS The human umbilical cord (UC) is a rich source of mesenchymal stromal cells (MSCs), which have been reported to have multi-lineage potential. The objectives of this study were to investigate the characteristics and capacity of UC-MSC neurosphere formation and whether this event enhances the propensity of UC-MSCs to undergo neural differentiation. METHODS UC-MSCs were collected by the improved explant method. UC-MSCs and neurosphere-forming UC-MSCs (UC-MSC-neurospheres) were… CONTINUE READING