Neuroserpin polymers cause oxidative stress in a neuronal model of the dementia FENIB

@inproceedings{Guadagno2017NeuroserpinPC,
  title={Neuroserpin polymers cause oxidative stress in a neuronal model of the dementia FENIB},
  author={Noemi Antonella Guadagno and Claudia Moriconi and Valerio Licursi and Emanuela D'Acunto and Paola Serena Nisi and Nicoletta Carucci and Antonella De Jaco and Emanuele Cacci and Rodolfo Negri and Giuseppe Lupo and Elena Miranda},
  booktitle={Neurobiology of Disease},
  year={2017}
}
The serpinopathies are human pathologies caused by mutations that promote polymerisation and intracellular deposition of proteins of the serpin superfamily, leading to a poorly understood cell toxicity. The dementia FENIB is caused by polymerisation of the neuronal serpin neuroserpin (NS) within the endoplasmic reticulum (ER) of neurons. With the aim of understanding the toxicity due to intracellular accumulation of neuroserpin polymers, we have generated transgenic neural progenitor cell (NPC… CONTINUE READING
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