Neuroserpin polymers activate NF-kappaB by a calcium signaling pathway that is independent of the unfolded protein response.

@article{Davies2009NeuroserpinPA,
  title={Neuroserpin polymers activate NF-kappaB by a calcium signaling pathway that is independent of the unfolded protein response.},
  author={Mark J. Davies and Elena Miranda and Benoit D. Roussel and Randal J Kaufman and Stefan J Marciniak and David A. Lomas},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 27},
  pages={18202-9}
}
The autosomal dominant dementia familial encephalopathy with neuroserpin inclusion bodies is characterized by the accumulation of ordered polymers of mutant neuroserpin within the endoplasmic reticulum of neurones. We show here that intracellular neuroserpin polymers activate NF-kappaB by a pathway that is independent of the IRE1, ATF6, and PERK limbs of the canonical unfolded protein response but is dependent on intracellular calcium. This pathway provides a mechanism for cells to sense and… CONTINUE READING