Neurosecretion competence. A comprehensive gene expression program identified in PC12 cells.

@article{Grundschober2002NeurosecretionCA,
  title={Neurosecretion competence. A comprehensive gene expression program identified in PC12 cells.},
  author={Christophe Grundschober and Maria Luisa Malosio and Laura Astolfi and Tiziana Giordano and Patrick C Nef and Jacopo Meldolesi},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 39},
  pages={36715-24}
}
The phenotype of neurosecretory cells is characterized by clear vesicles and dense granules, both discharged by regulated exocytosis. However, these organelles are lacking completely in a few neurosecretion-incompetent clones of the pheochromocytoma PC12 line, in which other specific features are maintained (incompetent clones). In view of the heterogeneity of PC12 cells, a differential characterization of the incompetent phenotype based on the comparison of a single incompetent and a single… CONTINUE READING

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