Neuroscientific Basis of Corticosteroid-Induced Changes in Human Cognitive and Emotional Processing: Implications for Affective Illness

  title={Neuroscientific Basis of Corticosteroid-Induced Changes in Human Cognitive and Emotional Processing: Implications for Affective Illness},
  author={Kymberly D. Young and Sheldon H. Preskorn},
  journal={Journal of Psychiatric Practice},
In this column, the authors first present a composite of several cases of psychiatrically healthy individuals who developed manic-depressive symptoms after receiving a course of prednisone to treat symptoms of inflammatory processes, such as Crohn’s disease. The next section summarizes keys points from 50 years of clinical experience with such cases. The authors then present an overview of the effects of exogenous administration of glucocorticoids on cognitive performance and emotional… 

Corticosteroid-induced psychiatric disturbances: It is time for pharmacists to take notice.

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Presentation of the Steroid Psychoses

  • Psychology, Medicine
    The Journal of nervous and mental disease
  • 1979
Patients receiving daily doses of 40 mg of prednisone or its equivalent, are at greater risk for developing steroid psychosis, and tricyclic antidepressants produced an exacerbation or worsening of the clinical state in all patients to whom they were administered.

Effects of Glucocorticoids on Mood, Memory, and the Hippocampus

  • E. Brown
  • Psychology, Medicine
    Annals of the New York Academy of Sciences
  • 2009
Hypomania and mania are the most common mood changes during acute corticosteroid therapy, although depression has also been reported, and moreover, depression is reported to be more common than mania during long‐term treatment with Corticosteroids.