Neuroscience of resilience and vulnerability for addiction medicine: From genes to behavior.

@article{Morrow2016NeuroscienceOR,
  title={Neuroscience of resilience and vulnerability for addiction medicine: From genes to behavior.},
  author={Jonathan D Morrow and Shelly B. Flagel},
  journal={Progress in brain research},
  year={2016},
  volume={223},
  pages={3-18}
}
Addiction is a complex behavioral disorder arising from roughly equal contributions of genetic and environmental factors. Behavioral traits such as novelty-seeking, impulsivity, and cue-reactivity have been associated with vulnerability to addiction. These traits, at least in part, arise from individual variation in functional neural systems, such as increased striatal dopaminergic activity and decreased prefrontal cortical control over subcortical emotional and motivational responses. With a… CONTINUE READING